Assessment of hot-melt coating methods for multiparticulate substrates: Mortar-coating vs. pan-coating

نویسندگان

چکیده

Hot-melt coating (HMC) is an alternative, solvent-free method generally used to modify substrate release rate and/or mask its unpleasant taste. The aim of this study was assess two HMC methods (pan-coating and mortar-coating) by assaying functional properties the coated material. selected substrates included highly soluble sodium chloride (model substance) caffeine (bitter drug), agent glycerol distearate without/with addition liquid paraffin. Experiments with revealed that pan-coating yielded particles more regular shape, while mortar-coating samples uniform layer. flowability material depended on particle size. Sustained achieved for all mortar-coated some pan-coated samples. analysis results indicated as a preferable coating. resulting yield in high (99%), showed satisfactory mechanical drug from sustained. Overall, obtained suggest both pan-and can be sustain drugs taste, but considered simple practical potentially compounding pharmacies.

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ژورنال

عنوان ژورنال: Arhiv za farmaciju

سال: 2021

ISSN: ['0004-1963', '2217-8767']

DOI: https://doi.org/10.5937/arhfarm71-30266